Dr Frank Mueller and Kim Engelman
Kimberly Engelman, MSN, APRN, FNP-BC and Dr. Frank Mueller, M.D.

O3 Plus, LLC was formed in February 2014 to be a catalyst for increased knowledge and awareness about Medical Ozone and its uses in health, wellness and research. The founding doctor of O3 Plus is Francis W. Mueller, MD, (“Dr. Frank”) who has been practicing family medicine in San Antonio since 1986.

In January 2016, Dr. Frank, along with Kimberly Engelman, RNC, FNP-BC, opened O3 Plus, LLC, an ozone therapy clinic, for the treatment of autoimmune, viral and other infectious diseases. He and his team of professionals are excited to be able to bring the healing attributes of ozone therapy to South Texas. His vision is to spearhead further research and acceptance of ozone therapy in mainstream American medicine.

Kimberly Engelman, MSN, APRN, FNP-BC

Classes | Workshops | Conferences

Ozone Therapy Training and Certification Course by Dr. Frank Shallenberger | April 2015 & January 2016
Beginning Prolozone® Course by Dr. Frank Shallenberger | April 2015
Advanced Prolozone® Course by Dr. Frank Shallenberger | September 2015
American Academy for the Advancement of Medicine (ACAM) Annual Meeting | November 2015
ACAM Basic Chelation Therapy Certification Course | November 2015
Methods of Ozone Therapy, Prolozone®, and Hyperbaric Ozone Autohemotherapy workshops by Dr. Robert Rowen and Dr. Terri Su. Included instruction on Zotzmann Hyperbaric Ozone Generator by Dr. Wolfgang Zotzmann and Lahodny Ozone High Dose Therapy by Dr. Johann Lahodny. Also included presentation on Direct IV Ozone by Dr. Howard Robbins | February 2016
American Academy of Ozonotherapy Annual Meeting | February 2016
Society of Progressive Medical Education Annual Conference (SOPMED) | June 2016
Aesthetic Ozone Workshop with Dr. Adriana Schwartz. Included instruction on treatments of acne, cellulite, alopecia, facial injections, and PRP | June 2016
ACAM Advanced IV Nutrients Therapy Workshop | September 2016
Women and Autoimmune Disease Course | October 2016
Frontiers in Ozone Conference | November 2016
Cosmetic Ozone Course by Dr. Marcelo Valio. Included instruction on localized fat, cellulite, hair, and facial rejuvenation | November 2016
Neural Therapy: Injection Therapies for Healing by Dr. Jeff Harris, N.D. | February 2017


American Academy for the Advancement of Medicine (ACAM)
American Academy of Ozonotherapy (AAOT): Active Fellow
American Association of Nurse Practitioners (AANP)
Ozone Without Borders, Society for the Advancement of Bio-Oxidative Therapy: Founding Member
San Antonio Nurses in Advanced Practice (SANAP)
Texas Nurse Practitioners (TNP)


  • Bachelor of Science in Communications from the University of Texas in Austin, 1997
  • Registered Nurse (RN) at Baptist School of Health Professions in San Antonio
  • Bachelor of Science in Nursing from Texas Tech University Health Sciences Center (TTUHSC) School of Nursing, 2010
  • Master of Science in Nursing (MSN) from Texas A&M in Corpus Christi, 2013
  • Certified in In-Patient Obstetrics by the National Certification Corporation, RNC-OB, 2010
  • Certified as a Family Nurse Practitioner by the American Nurses Credentialing Center, 2013

Frank Mueller, M.D.

Dr. Frank is pioneer and researcher in this new field of medical ozone, although his medical degree and background are in traditional medicine.


  • Completed pre-medical studies at St. Mary’s University in San Antonio
  • Graduated with a Doctor of Medicine (M.D.) from Texas Tech University Health Sciences Center (TTUHSC) School of Medicine, 1983
  • Board Certified in Family Medicine, 1986
  • Earned designation as a Castle Connolly “Top Doctor,” 2011-2014
  • Became a Fellow of the American Academy of Ozonotherapy, 2014

Dr. Frank practiced traditional medicine for 27 years. In February 2013, at the urging of his uncle, William R. Mueller, DDS, he attended the first inaugural International Academy of Ozone in Healthcare and Dentistry (IAOHD) meeting in Las Vegas.

Dr. Frank describes the inaugural IAOHD convention in his own words:

I was blown away! Here you had doctors from all over the world — Germany, Egypt, Cuba, South America, England, and the US — all using this natural substance [ozone] for decades — which I had never learned about in medical school — and all getting amazing results on a wide variety of conditions with nearly no side-effects. These conditions included some of the toughest we face in medicine: chronic fatigue, fibromyalgia, auto-immune diseases, cancer, degenerative arthritis, etc. I could not pull myself away from hearing the incredulous stories and research. If ozone could add so much to areas where traditional medicine was lacking, we could make a quantum leap forward in medical care by learning and using it properly.

Since then, Dr. Frank has taken ozone courses taught by Dr. Frank Shallenberger, Dr. Bill Domb, Dr. Howard Robins, Dr. Robert Rowen, and Dr. Sylvia Menendez of Cuba.